منابع مشابه
Neurosteroid 3α-Androstanediol Efficiently Counteracts Paclitaxel-Induced Peripheral Neuropathy and Painful Symptoms
Painful peripheral neuropathy belongs to major side-effects limiting cancer chemotherapy. Paclitaxel, widely used to treat several cancers, induces neurological symptoms including burning pain, allodynia, hyperalgesia and numbness. Therefore, identification of drugs that may effectively counteract paclitaxel-induced neuropathic symptoms is crucial. Here, we combined histopathological, neurochem...
متن کامل3α-Androstanediol, but Not Testosterone, Attenuates Age-Related Decrements in Cognitive, Anxiety, and Depressive Behavior of Male Rats
Some hippocampally-influenced affective and/or cognitive processes decline with aging. The role of androgens in this process is of interest. Testosterone (T) is aromatized to estrogen, and reduced to dihydrotestosterone (DHT), which is converted to 5alpha-androstane, 3alpha, 17alpha-diol (3alpha-diol). To determine the extent to which some age-related decline in hippocampally-influenced behavio...
متن کاملStudies of lymphocyte kinetics in man.
VAST LITERATURE dealing with lymphocyte kinetics has accumulated since the early attempts of Minot and Isaacs in 1925 to determine the survival of transfused leukemic lymphocytes.1 Most of these studies have been done in animals because of the obvious limitations in studying thoracic duct output in man. Nevertheless, some important questions appear to have been clarified. The controversy over t...
متن کاملThe Kinetics of Granulopoiesis in Normal Man.
I N 1955, when studies were initiated in our laboratory to determine the suitability of radioactive diisopropylfluorophosphate ( DFP32) as a label for granulocytes, information concerning the rate of production and movement of these cells was very meager as compared with knowledge of erythrokinetics. Since that time, with the development and application of the DFP32 cytoplasmic granulocyte labe...
متن کاملthe tragedy of modern man in arthur millers world
what miller wants is a theatre of heightened consciousness. he speaks of two passions in a man, the passion to "feel" and the passion "know". he belives that we can have more of the latter. he says: drama is akin to the other inventions of man in that it ought to help us know more and not merely to spend our feelings. the writing of the crucible shows us that he is trying to give more heightene...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1974
ISSN: 0021-9738
DOI: 10.1172/jci107802